China 67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-etil ester Produsen lan Pabrik |Jiayinglai

67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester

Katrangan singkat:

Penampilan	Kristal putih nganti Putih utawa bubuk kristal.
MF	C16H22N2O6
MW	338.36
Kemurnian	98+

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Detail Produk

Kondisi transportasi & metode pengiriman sing disaranake:
kanthi udhara, segara utawa kanthi ekspres

Kondisi panyimpenan:
Disegel ing garing, Suhu Kamar

Jumlah Pesanan Minimal:
Rembugan

Sertifikasi:
COA, HPLC, GC, HNMR, Assay, Water Content (KF), TLC kasedhiya

sinonim

(S)-etil 2-(tert-butoxycarbonylaMino)-3-(4-nitrofenil)propanoat;
Boc-(4-NO2)-L-Phe-OEt;
Boc-(4-NO2)-Oet;
Boc-Phe(4-NO2)-Oet;
L-Fenilalanin;
N-[(1,1-dimethylethoxy)karbonil]-4-nitro-, etil ester

Packing batin

Biasane digunakake kanggo ngemas bubuk.Lan bisa nyegah sinar srengenge lan banyu dadi ala.

packing njaba

Karton sing keras bisa nglindhungi produk sampeyan supaya ora nabrak lan udan.

Aplikasi

Nidanib, iku kimia.Jeneng kimia 1 h - indole - 6 - asam karboksilat, 2, 3 - dihidro - 3 - [[[4 - (metil [(4 - metil - 1 - piperazine) asetil] amino] fenil] amino] benzena jantung metil] - 2 - oksigen -, metil ester, (z) - Sacara klinis, produk iki digunakake kanggo nambani fibrosis paru idiopatik (IPF).
Nidanib wis nyinaoni 1,529 pasien kanthi fibrosis paru idiopatik (IPF) ing pirang-pirang uji klinis.Data safety sing disedhiyakake adhedhasar perbandingan pasien 1061 sing diwenehi nidanib 150 mg kaping pindho saben dina lan plasebo ing rong fase 52 minggu 3, studi acak, buta ganda, kontrol plasebo (INPULSIS-1 lan INPULSIS-2).Efek samping sing paling umum sing digandhengake karo panggunaan nidanib kalebu diare, mual lan muntah, nyeri weteng, mundhut napsu, mundhut bobot, lan enzim ati sing dhuwur.Mangga deleng [Precautions] kanggo manajemen reaksi salabetipun sing cocog.Klasifikasi Organ Sistematik (SOC) MedDRA nyedhiyakake ringkesan reaksi salabetipun lan klasifikasi frekuensi.
Nidanib minangka substrat kanggo P-gp (pirsani Farmakokinetik).Ing panaliten khusus babagan interaksi obat, administrasi gabungan ketoconazole, inhibitor P-gp sing kuat, nambah paparan nidanib nganti 1,61 kali miturut area ing kurva (AUC) lan 1,83 kali kanthi konsentrasi puncak (Cmax).
Ing studi interaksi obat karo rifampicin inducer P-gp sing kuat, paparan nidanib mudhun dadi 50,3%, sing diukur kanthi area ing sangisore kurva (AUC), nalika digabungake karo rifampisin dibandhingake karo Nidanib mung.Miturut konsentrasi puncak (Cmax), mudhun nganti 60,3%.
Nalika digabungake karo produk iki, inhibitor P-gp sing kuat (contone, ketokonazol utawa eritromisin) bisa nambah paparan nidanib.Ing kasus kasebut, toleransi pasien kanggo nidanib kudu dipantau kanthi rapet.Manajemen reaksi salabetipun bisa uga mbutuhake mandheg, nyuda dosis, utawa mungkasi perawatan karo produk iki (pirsani [Panganggone lan dosis]).
Inducers kuat P-gp (contone, rifampicin, carbamazepine, phenytoin lan St. John's wort) bisa nyuda paparan nidanib.Kombinasi alternatif kanthi induksi P-gp ora utawa minimal kudu dianggep.

produk sing gegandhengan

Gly-Phe	Boc-Phe-Gly-Ome	HN-Me-L-Phe.Hcl	Boc-D-Phe-D-Phe
Boc-D-4-Chloropheny(alanine)	Fmoc-L-Phe-OH	L-Phe-NH2.Hcl	Boc-Phe-Gly
L-Ala-Phe-OH	Fmoc-D-Phe-OH	4-NO2-Phe-Oet	Boc-L-Phe-Onp
Boc-Ala-Phe-OH	Fmoc-N-Me-L-Phe-OH	4-NO2-Phe-Oet.HCl	Boc-L-Phe-Oet
Boc-Ala-Phe-OH	FMOC-N-Me-D-Phe-OH	HD-Phe-OMe·HCl	Boc-4-NO2-D-Phe-OEt
Fmoc-β-Ala-D-phe	Fmoc-Phe-Cl	HL-Phe-OMe.HCl	Boc-D,L-Phe(4-NO2)-OH
Leu-Phe.Hcl	Fmoc-Phe(4-NO2)-OH	H-DL-Phe-OBzl .tos	Fmoc-Phe-Phe-OH
Boc-Leu-Phe	Cbz-L-Phe-OH	H-DL-Phe(4-NO2)-OH.H2O	Fmoc-Phe-Gly-OH
Cbz-L-Phe-Leu-OH	Cbz-D-Phe-OH	HL-Phe-OBzl.HCl	Fmoc-D-Phe(4-NO2)-OH
L-Phe	Cbz-DL-Phe-OH	HL-Phe-OEt.HCl	Cbz-Phe-Arg-OH
HD-Phe-OH	Cbz-D-Phe-OL	L-Phe-NH2	Cbz-Phe-Ala-OH
L-Phe-NCA	ZN-Me-L-Phe-OH	D-Phe-NH2	Cbz-Phe-Gly-OH
Tos-Phe	cbz-L-Phe-OSU	N-Ac-L-Phe-OH	Cbz-Phe-Met-OH
L-Phe-ol	Phe-Ala	N-AC-L-Phe-Ome	Cbz-Phe-Gly-Oet
L-Phe(4-NO2)-OH	L-Phe-Phe	N-Pht-Phe-OH	Boc-Phe-Gly-Gly-OH
L-Phe(4-NO2).H2O	L-Phe-Trp	Boc-Phe-OH	Fmoc-L-Thr(tBu)-Phe-OH
D-Phe(4-NO2)-OH.h2o	L-Phe-Leu-OH	Boc-D-Phe-OH	D-Phe-NH2
D-Phe(4-NO2)-OH	L-Phe-Tyr-OH	Boc-DL-Phe-OH	Tyr-Phe
N-Aku-D-Phe	L-Phe-Gly	BOC-N-Me-D-Phe-OH	DL-Phe-Ome.Hcl
HN-Me-L-Phe-OH	D-Phe-D-Phe	Boc-N-Me-DL-Phe-OH	Boc-Met-Leu-Phe
L-Phe.hcl	L-Phe-OBzl-OH	Boc-N-Me-L-Phe-OH	Asp-Phe-Ome
4-NO2-D-phe.hcl	D-Phe-Obzl.Tos	Boc-N-Me-L-Phe-OH.DCHA	L-Homophe-OH
HL-Phe-OtBu.HCl	Boc-Phe-Ala-OH	Boc-DN-Me-Phe•DCHA	D-Homophe-OH
HD-Phe-OtBu.HCl	Boc-Phe-Leu-OH	Boc-Phe-Ol	L-Homophe-Oet.Hcl
D,L-Phe-OtBu HCl	Boc-Phe-Trp-OH	Boc-D-Phe-Ol	D-Homophe-Oet.HCl
HD-Phe(4-NO2)-Ome.HCl	Boc-L-Phe-Tyr-OH	Boc-Phe-NH2	Boc-L-Homophe-OH
D-Phe-Obzl.Hcl	Boc-Phe-Phe-OH	Boc-L-Phe-Ome	Boc-D-Homophe-OH
DL-Phe-Ome.Hcl	Boc-D-Phe-Phe	Boc-D-Phe-Ome	Fmoc-L-HomoPhe-OH
Boc-D-Phe(4-NO2)-OH	Cbz-D-Homophe-OH	Boc-Phe-Obzl	Fmoc-D-Homophe-OH
Boc-L-Phe-OSU	Boc-Homophe-Leu-Phe-Ome	Boc-4-NO2-Phe-OH	Cbz-L-Homophe-OH
Boc-D-Phe-OSU

kaunggulan

1. Layanan R&D kasedhiya
2. Produsen sertifikat ISO, jaminan kualitas
3.A mesthi lengkap layanan tindakake-munggah sak produksi
4. Biaya efektif dhuwur
5. Dokumen sertifikasi kualitas diwenehake saben panyuwunan pelanggan
6.Great layanan sawise-sales, ngramut sesambetan cedhak karo customer
7. Sumber daya lengkap kanggo mbantu nyuda biaya pengiriman
8. Sampel gratis sing ditawakake kanggo mriksa kualitas sadurunge pembayaran
9. istilah pembayaran rembugan
10. Assit pelanggan menehi hasil karo urusan ing China